Dr Sean Lal
BMedSci (Hons1), MBBS (Hons) (USYD), MPhil(Med), PhD(Med), FRACP
- Clinical Academic Cardiologist, University of Sydney and Royal Prince Alfred Hospital
- Consultant Cardiologist, Chris O'Brien Lifehouse
- Consultant Cardiologist, Strathfield Private Hospital
Dr Sean Lal is an Academic at the University of Sydney and a Consultant Cardiologist at Royal Prince Alfred Hospital. He completed his undergraduate degree in Medical Science with first class honours at the University of Sydney, having been awarded a full academic scholarship. He pursued his graduate Medical Degree (MBBS) and a Master of Medicine by research (MPhil) at the University of Sydney, where he was awarded the Dean's Scholarship, the Medical Foundation Scholarship and the University of Sydney Bercovici Medal. As a medical doctor, Sean completed all of his general and specialty clinical training at Royal Prince Alfred Hospital. During his cardiology training, he was awarded a National Churchill Fellowship to study mechanisms of cardiac regeneration at Harvard Medical School.
Sean has a clinical and research interest in heart failure. For his PhD in this field, he was awarded a combined National Health and Medical Research Council (NHMRC) and National Heart Foundation (NHF) Scholarship, as well as the NHMRC and Royal Australasian College of Physicians (RACP) scholarship for research excellence.
He was also awarded a Commonwealth Endeavour Postgraduate Fellowship to Harvard University and Massachusetts Institute of Technology (MIT), where he undertook proof of concept studies demonstrating the intrinsic regenerative capacity of the human heart following myocardial infarction.
Sean is Block Chair for Cardiovascular Medicine. He is also a Senior Lecturer in Visceral Anatomy and the Course Coordinator for Cardiac, Endocrine, Abdominal, Pelvic and Renal Anatomy for the Sydney Medical (MD) Program.
Sean is the Director of the Sydney Heart Bank and the Head of the Cardiac Research Laboratory in the School of Medical Sciences at Charles Perkins Centre, which focuses on basic science and translational research into human heart failure. He is also the Chair of the Heart Failure Council for Australia and New Zealand.
In a collaboration with Dr John O'Sullivan, also from the Charles Perkins Centre, Sean and John have established the Precision Cardiovascular Laboratory, which aims to correlate serum biomarkers of cardiovascular disease with pathogenic and age-related changes in human heart tissue via integration of the cardiac genome, transcriptome, metabolome and proteome.
Cardiac imaging including transesophageal echocardiography
Cardiac regeneration strategies
Teaching in the medical sciences
Lal, S.P., Christopherson, R.I. and dos Remedios, C.G. Antibody arrays: an embryonic but rapidly growing technology. (2002) Drug Discovery Today 7: 18: s143-s149.
Lal, S.P., Lui, R., Nguyen, L., Macdonald, P., Denyer, G. and dos Remedios, C.G. Increases in Leukocyte CD Antigen Expression During Cardiopulmonary Bypass in Patients Undergoing Heart Transplantation. (2004) Proteomics 4(7):1918-26
Lal, S.P.,Bannon, P., Nguyen, L., Denyer, G. and dos Remedios, C.G. Changes in CD antigen expression in on-pimp and off-pump coronary artery grafting surgery. (2004) Journal of Molecular and Cellular Cardiology 37(1): 220-221.
Lui, R., Lal, S.P and dos Remedios, C. G. (2005) Book Chapter Proteomics in Cardiovascular Disease in Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer Encyclopedia Reference, Springer-Verlag, Heidelberg. pg 1567-1569.
Lal, S.P., Brown, A., Nguyen, L., Braet, F., Dyer, W., and dos Remedios, C.G. Using antibody arrays to detect microparticles from acute coronary syndrome patients based on CD antigen expression. (2009) Molecular and Cellular Proteomics April 799-804
Alana N. Mohamed, Sean Lal, Joshua W.K. Ho, Angus Brown, Rodney Lui, Lisa Nguyen, Andy S.C. Yong, Yingying Su, Filip Braet, Wayne Dyer, Frank Junius, Robert G. Cumming, S. Benedict Freedman, Leonard Kritharides, Cristobal G. dos Remedios. (2010) Book Chapter Myocardial Ischemia: Causes, Symptoms and Treatment. Nova Publishers. Chapter title: How to Interrogate the Cellular Immune System in Patients with Ischemic Heart Disease.
Lal, S and dos Remedios, C.G. Is there a connection between apoptosis and atrial fibrillation? (2010) Cardiology; 117:161-162
Helen Cahill, Aaron Jones, Robert Herkes, Kathy Cook, Anne Stirling, Tanya Halbert, Amanda Yates, Sean Lal, Alan Gardo, Roy Donnelly, David Gattas on behalf of the Royal Prince Alfred Hospital Clinical Emergency Response System Steering Committee. Introduction of a new observation chart and education program is associated with higher rates of vital sign ascertainment in hospital wards. (2011) British Medical Journal Quality and Safety; March edition
Sean Lal and Cristobal G. dos Remedios. Tissue Microarrays: Methods and Protocols. (2011) Proteomics; 11: 3436 (Issue 16)
James Erle Wolfe, Shin’ichi Ishiwata, Filip Braet, Renee Whan, Yingying Su, Cristobal G. dos Remediosand Sean Lal. SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation. (2011) Biophysical Reviews; 3; 53-62
Cristobal G Dos Remedios, James E Robinson, Renee Whan, Filip Braet, Yingying Su, Theresia Kraft, Jolanda van der Velden, Steven B Marston, Marja Steenman, Peter S Macdonald, Sean Lal. Quantifying the contractile performance of human cardiomyocytes. (2011) Biophysical Journal 100 (3) 298a
S. Lal, L. Nguyen, F. Ponten, J. Odeberg, C. Remedios. Tissue microarray profiling of four-and-a-half LIM protein in human heart failure. (2012) Heart Lung and Circulation 21, S97
Li, A., Estigoy, C., Raftery, M., Odeberg, J., Ponten, F., Lal, S., dos Remedios, C. How to use public resources in heart research: Human protein atlas and the Sydney heart bank. (2013) Heart Lung and Circulation 22 (10), 819-826
Tamara T. Koopmann1, Michiel E. Adriaens, Perry D. Moerland, Roos F. Marsman, Margriet L. Westerveld, Sean Lal, Taifang Zhang, Christine Q. Simmons, Istvan Baczko, Cristobal dos Remedios, Nanette H. Bishopric, Andras Varro, Alfred L. George, Jr., Elisabeth M. Lodder, Connie R. Bezzina. Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart. (2014) PlosOne 9(5): e97380
Zijun Ge, Sean Lal, Loan Le, James Chong. Cardiac stem cells: translation to human studies. (2014) Biophysical Reviews 12/2014.
Belinda Gray, Paul Bannon, Brian Bailey, Sean Lal, Laura Yeates, David Richmond, Michael Byrom, Christopher Semsarian, Caroline Medi. A surgical myectomy program to manage complex obstructive hypertrophic cardiomyopathy. (2015) Heart, Lung and Circulation 24(3): S175
Sean Lal, Amy Li, David Allen, Paul Allen, Paul Bannon, Tim Cartmill, Roger Cooke, Alan Farnsworth, Anne Keogh and Cristobal dos Remedios. Best practice bio-banking of human heart tissue. (2015) Biophysical Reviews Dec 7(4): 399-406.
Sean Lal, Amy Li and Cris dos Remedios. Limitations in translating animal studies to humans in cardiovascular disease. (2016) Journal of Cardiovascular Translational Research April 9(2): 165-6
James McNamara, Amy Li, Nicola Smith, Sean Lal, Bob Graham, KB Kooiker, Jenny Van Diik, Cris dos Remedios, Samantha Harris and Roger Cooke. Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes. (2016) Journal of Molecular and Cellular Cardiology March 26(94): 65-71
Sean Lal, Lisa Nguyen, Rhenan Tezone, Fredrik Ponten, Jacob Odeberg, Amy Li and Cristobal dos Remedios. Tissue MicroArray (TMA) Profiling in Human Heart Failure. (2016) Proteomics September 16(17): 2319-26.
Sean Lal, Lisa Turner, Catherine Powell, Michael Wilson and Paul Bannon. Improvements in Left Ventricular Ejection Fraction and Quality of Life in Patients with Heart Failure who undergo Coronary Artery Bypass Surgery. (2016) International Journal of Cardiology Volume 222 (1), Pages 671–673
Nelson Wang and Sean Lal. Post-dilation in Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-analysis. (2017) Journal of Interventional Cardiology Mar 21
Crossman DJ, Shen X, Jüllig M, Munro M, Hou Y, Middleditch M, Shrestha D, Li A, Lal S, Dos Remedios CG, Baddeley D, Ruygrok PN, Soeller C. Increased collagen within the transverse tubules in human heart failure. (2017) Cardiovasc Research. 2017 Apr 20
McNamara JW, Li A, Lal S, Bos JM, Harris SP, van der Velden J, Ackerman MJ, Cooke R, Dos Remedios CG. MYBPC3 Mutations are associated with a reduced Super-relaxed State in patients with Hypertrophic Cardiomyopathy. (2017) PLoS One Jun 28;12(6):e0180064.
C. G. dos Remedios, S. P. Lal, A. Li, J. McNamara, A. Keogh, P. S. Macdonald, R. Cooke, E. Ehler, R. Knöll, S. B. Marston, J. Stelzer, H. Granzier, C. Bezzina, van Dijk, F. De Man, G. J. M. Stienen, J. Odeberg, F. Pontén, W. Linke, J. van Velden. The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease. (2017) Biophysical Reviews 14th August
Jim Ge and Sean Lal. Human Cardiac Regeneration: New Cells in Old Hearts Revisited. (2017) Cardiology Today 7(2): 17-19
Ranganath Mamidi, Jiayang Li, Kenneth S. Gresham, Chang Yoon Doh, Amy Li, Sean Lal, Cristobal G. dos Remedios and Julian E. Stelzer. Dose-dependent effects of the myosin activator omecamtiv mecarbil on cross-bridge behavior and force generation in failing human myocardium. (2017) Circulation Heart Failure 10(10) 1-11
Nelson Wang, Jordan Fulcher, Nishan Abeysuryia, Mark Adams, Sean Lal. Predictors of Successful Chronic Total Occlusion Percutaneous Coronary Interventions: A systematic review and meta-analysis. (2017) BMJ Heart pii: heartjnl-2017-311986
Sean Lal, Irina Kotchetikova, Jacob Cao, Daniel Jackson, Rachael Cordina and David S Celermajer. Heart failure admissions and poor subsequent outcomes in adults with congenital heart disease. (2017) European Journal of Heart Failure20(4):812-815
Petr Vikhorev, Natalia Smoktunowicz, Alex Munster, O’Neal Copeland. Sawa Kostin, Cecile Montgiraudi, Andrew Messer, Mohammad Toliat, Amy Li, Cristoboal dose Remedios, Sean Lal, Cheavar Blair, Kenneth Campbell, Maya Guglin, Ralph Lnoll, Steven Marston. Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes. (2017) Scientific Reports 7(1):14829
Jacob Cao, S Yee, Kevin Pham, David Celermajer, Sean LalRenin-angiotensin-aldosterone inhibition improves right ventricular function: a meta-analysis. (2018) Heart Asia10(1)
Sean Lal Cardiovascular Risk in Primary Sjrogen’s Syndrome. (2018) New England Journal of Medicine 379(1):96-7
Richard Bagnall, Jodie Ingles, Marcel E. Dinger, Mark J. Cowley, Samantha Barratt Ross, André E. Minoche, Sean Lal, Christian Turner, Alison Colley, Sulekha Rajagopalan, Yemima Berman, Anne Ronan, Diane Fatkin, Christopher Semsarian. Whole Genome Sequencing improves outcomes in patients with hypertrophic cardiomyopathy. (2018) Journal of the American College of Cardiology 72 (4): 419-429
Nelson Wang, Jordan Fulcher, Nishan Abeysuriya, Michele McGrady, Ian Wilcox, David Celermajer, Sean Lal. Tricuspid Regurgitation is associated with increased mortality independent of pulmonary pressures and right heart failure. (2019) European Heart Journal 40, 476-484.
This article was editorialised European Heart Journal (2019) 40, 485–487.
Li A, Lal S, Dos Remedios CG. A step towards understanding the molecular nature of human heart failure: advances using the Sydney Heart Bank collection. (2019) Biophys Rev. Apr; 11(2):241-244.
Jacob Cao, Yen Chin Koay, Lake-Ee Quek, Benjamin Parker, Sean Lal*, John O’Sullivan* (*co-senior authors). Myocardial Metabolic Perturbations in Advanced Ischemic and Non-Ischemic Dilated Human Heart Failure. (2019) European Journal of Heart Failure. 21(8), 1042-1045.
Liu, C., Lim, S., Teo, M., Tan, M., Kulkarni, M., Qiu, B., Li, A., Lal, S., Dos Remedios, C., Tan, N., et al (2019). Collaborative Regulation of LRG1 by TGF-B1 and PPAR-B/8 Modulates Chronic Pressure Overload-Induced Cardiac Fibrosis. Circulation. Heart Failure, 12(12), e005962.
Wang, N., Fulcher, J., Abeysuriya, N., Park, L., Kumar, S., Di Tanna, G., Wilcox, I., Keech, A., Rodgers, A., Lal, S. (2020). Intensive LDL cholesterol-lowering treatment beyond current recommendations for the prevention of major vascular events: a systematic review and meta-analysis of randomised trials including 327037 participants. The Lancet Diabetes & Endocrinology, 8(1), 36-49.