Profile
A/Prof Mark Adams
- Associate Professor of Medicine, Sydney Medical School, University of Sydney
- Senior Staff Specialist, Department of Cardiology, Royal Prince Alfred Hospital
- Cardiologist (Visiting Medical Officer), Strathfield Private Hospital
A/Prof Mark R. Adams is one of Australia’s leading interventional cardiologists, with extensive experience in complex coronary intervention. He has performed over 6,000 coronary angioplasty and stenting procedures, many of them complex and clinically challenging.
He graduated with First Class Honours in Medicine from the University of Sydney in 1987 and trained in cardiology at Royal Prince Alfred Hospital. His PhD at the Heart Research Institute, on the cellular mechanisms of early coronary atherosclerosis, led to the award of the Cardiac Society of Australia and New Zealand’s Ralph Reader Prize in 1996.
He trained in coronary angioplasty at the Brigham and Women’s Hospital and Harvard Medical School, Boston, and was appointed Staff Specialist in Cardiology at Royal Prince Alfred Hospital in 1999, where he was Head of the Department of Cardiology for 17 years.
He has over 70 publications, including in the New England Journal of Medicine, with more than 4,600 citations.
With over 25 years in general cardiology, his special interests are complex, acute and chronic coronary heart disease and its non-invasive (echocardiography) and invasive assessment and treatment. He has also been keenly sought for expert opinion in cardiology medico-legal matters for many years.
- Complex coronary interventions
- Coronary artery function and physiology
- Atherosclerosis and endothelial function including intravascular ultrasound
- Intracoronary imaging
- Endomyocardial biopsy
- Alcohol septal ablation for hypertrophic obstructive cardiomyopathy
Selected Publications:
Drak D, Fulcher J, Kilian J, Chong JJH, Grover R, Sindone AP, Adams M, Lattimore JD, Keech AC. Guideline-based audit of the hospital management of heart failure with reduced ejection fraction. Internal Medicine Journal 2023;53(9):1595-1601.
Rehan R, Kempler E, McMaster K, Larnach G, Amos D, Elder A, Arnold R, Juergens C, Patel S, Weaver J, Ng M, Roy P, Yong A, Brieger D, Kritharides L, Adams M, Lowe H. In-hospital outcomes for high-risk percutaneous coronary intervention (PCI) in patients referred from a rural centre to metropolitan sites. Heart, Lung & Circulation 2022;31(2):224-229.
Karimi Galougahi K, Patel S, Adams M. Invasive or conservative strategy for stable coronary disease. N Engl J Med 2020;383(10):e66.
Wang N, Fulcher J, Abeysuriya N, Adams M, Lal S. Predictors of successful chronic total occlusion percutaneous coronary interventions: a systematic review and meta-analysis. Heart 2018;104(6):517-524.
Spina R, Forrest A, Adams M, Wilson M, Ng M, Vallely M. Veno-Arterial Extracorporeal Membrane Oxygenation for High-Risk Cardiac Catheterisation Procedures. Heart, Lung & Circulation. 2010; 19:736-41.
Ilsar R, Levitt J, Ng M, Kritherides L, Adams MR, Celermajer DS. Bosentan and Improved Pulmonary Endothelial Function in Pulmonary Arterial Hypertension. European Respiratory Journal
Kathir K, Dennis J, Croft K, Mori T, Lau A, Adams M, Stocker R. Equivalent lipid oxidation profiles in advanced atherosclerotic lesions of carotid endarterectomy plaques obtained from symptomatic type 2 diabetic and non-diabetic subjects. Free Radical Biology and Medicine, 2010;49(3):481-6
McGrady M, Thanyasiri P, Bailey BP, Celermajer DS, Adams MR. Determinants of coronary flow-mediated dilatation following percutaneous coronary intervention. Catheterization and Cardiovascular Interventions 2008;71:327-32.
Wu BJ, Kathir K, Witting PK, Beck K, Choy K, Li C, Croft KD, Mori TA, Tanous D, Adams MR, Lau AK, Stocker R. Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging. Journal of Experimental Medicine 2006; 203:1117-1127.
Thanyasiri P, Celermajer DS, Adams MR. Endothelial dysfunction occurs in the peripheral circulation in patients with acute and stable coronary artery disease. Am J Physiol 2005;289:H513-517.
Adams MR, Blake GJ, Byrne JG, Orford JL, Wainstein MV, Selwyn AP, Popma JJ. Rescue PCI following CABG – A descriptive analysis of the changing interface between interventional cardiologist and cardiac surgeon. Clin Cardiol 2002;25:280-286.
Adams MR, Kinlay S, Blake GJ, Orford JL, Ganz P, Selwyn AP. Pathophysiology of atherosclerosis: development, regression, restenosis. Curr Atheroscler Reports 2000;2:251-258
Adams MR, Phu CV, Stocker R, Celermajer DS. Lack of antioxidant activity of the antiatherogenic compound L-arginine. Atherosclerosis 1999;146:329-335.
Adams MR, Robinson JTC, McCredie RJ, Seale JP, Sorensen KE, Celermajer DS. Smooth muscle dysfunction occurs independently of impaired endothelium-dependent dilatation in adults at risk of atherosclerosis. J Am Coll Cardiol 1998;32:123-127
Adams MR, Jessup W, Hailstones D, Celermajer DS. L-arginine reduces human monocyte adhesion to vascular endothelium and endothelial expression of cell adhesion molecules.Circulation1997;95:662-668.
Adams MR, Jessup W, Celermajer DS. Cigarette smoking is associated with increased monocyte adhesion to endothelial cells in humans: reversibility with L-arginine but not vitamin C. J Am Coll Cardiol 1997;29:491-497.
Celermajer DS, Adams MR, Robinson J, McCredie R, Donald A, Clarkson P, Deanfield JE. Passive smoking is associated with impaired endothelium-dependent dilation in healthy young adults. N Engl J Med 1996;334:150-4.
Adams MR, Nakagome A, Keech A, Robinson J, McCredie R, Bailey BP, Freedman SB, Celermajer DS. Carotid intima-media thickness is only weakly correlated with the extent and severity of coronary artery disease. Circulation 1995;92:2127-2134.
Adams MR, Forsyth CJ, Jessup W, Robinson J, Celermajer DS. Oral L-arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilation in healthy young men. J Am Coll Cardiol 1995;26:1054-61.