Profile
A/Prof Sean Lal
- Associate Professor of Medicine, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney
- Consultant Cardiologist and Director of Acute Heart Failure Services, Department of Cardiology, Royal Prince Alfred Hospital
- VMO Lifehouse Hospital and Strathfield Private Hospital
Sean Lal is an Associate Professor of Medicine and Medical Sciences in the Faculty of Medicine and Health at the University of Sydney. He is also a Consultant Cardiologist in the Department of Cardiology at Royal Prince Alfred Hospital, where he is the Director of Acute Heart Failure Services.
Sean completed his undergraduate degree in Medical Science with first class honours at the University of Sydney, receiving full academic scholarship. He pursued his graduate Medical Degree (MBBS) and a Master of Medicine by research (MPhil) at the University of Sydney, where he was awarded the Dean’s Scholarship, the Medical Foundation Scholarship, and the University of Sydney Bercovici Medal. As a medical doctor, Sean completed his general and specialty training at Royal Prince Alfred Hospital. During his cardiology training, he was awarded a National Churchill Fellowship to study mechanisms of cardiac regeneration at Harvard Medical School, USA.
Sean has clinical and research training in heart failure. For his PhD in this field, he was awarded a combined National Health and Medical Research Council (NHMRC) and National Heart Foundation (NHF) Scholarship, as well as the NHMRC and Royal Australasian College of Physicians (RACP) prize for research excellence.
Following cardiology training, Sean completed an overseas clinical and basic sciences fellowship in Boston, USA. He was awarded a National Endeavour Postgraduate Scholarship by the Australian Government to Harvard University and Massachusetts Institute of Technology (MIT), where he undertook molecular studies demonstrating the intrinsic regenerative capacity of the human heart after myocardial infarction, whilst also leading Attending Rounds in acute heart failure management in the Cardiac ICU at the Brigham and Women’s Hospital.
Sean’s research laboratory in the School of Medical Sciences at the University of Sydney focuses on basic science and translational research into the molecular pathways of human heart failure, cardiac ageing, and cardiac regeneration. He is also Co-Director for The Centre for Heart Failure and Diseases of the Aorta, a partnership formed by the Baird Institute, the University of Sydney, and Royal Prince Alfred Hospital.
- General cardiology
- Arrhythmias
- Cardiac imaging including transesophageal echocardiography
- Heart failure
- Cardiac regeneration strategies
- Teaching in the medical sciences
Lal, S.P., Christopherson, R.I. and dos Remedios, C.G. Antibody arrays: an embryonic but rapidly growing technology. (2002) Drug Discovery Today 7: 18: s143-s149.
Lal, S.P., Lui, R., Nguyen, L., Macdonald, P., Denyer, G. and dos Remedios, C.G. Increases in Leukocyte CD Antigen Expression During Cardiopulmonary Bypass in Patients Undergoing Heart Transplantation. (2004) Proteomics 4(7): 1918-26
Lal, S.P., Bannon, P., Nguyen, L., Denyer, G. and dos Remedios, C.G. Changes in CD antigen expression in on-pump and off-pump coronary artery grafting surgery. (2004) Journal of Molecular and Cellular Cardiology 37(1): 220-221.
Lui, R., Lal, S.P and dos Remedios, C. G. (2005) Book Chapter Proteomics in Cardiovascular Disease in Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer Encyclopedia Reference, Springer-Verlag, Heidelberg. pg 1567-1569.
Lal, S.P., Brown, A., Nguyen, L., Braet, F., Dyer, W., and dos Remedios, C.G. Using antibody arrays to detect microparticles from acute coronary syndrome patients based on CD antigen expression. (2009) Molecular and Cellular Proteomics April 799-804
Alana N. Mohamed, Sean Lal, Joshua W.K. Ho, Angus Brown, Rodney Lui, Lisa Nguyen, Andy S.C. Yong, Yingying Su, Filip Braet, Wayne Dyer, Frank Junius, Robert G. Cumming, S. Benedict Freedman, Leonard Kritharides, Cristobal G. dos Remedios. (2010) Book Chapter Myocardial Ischemia: Causes, Symptoms and Treatment. Nova Publishers. Chapter title: How to Interrogate the Cellular Immune System in Patients with Ischemic Heart Disease.
Lal, S and dos Remedios, C.G. Is there a connection between apoptosis and atrial fibrillation? (2010) Cardiology; 117:161-162
Helen Cahill, Aaron Jones, Robert Herkes, Kathy Cook, Anne Stirling, Tanya Halbert, Amanda Yates, Sean Lal, Alan Gardo, Roy Donnelly, David Gattas on behalf of the Royal Prince Alfred Hospital Clinical Emergency Response System Steering Committee. Introduction of a new observation chart and education program is associated with higher rates of vital sign ascertainment in hospital wards. (2011) BMJ Quality and Safety; March edition
Sean Lal and Cristobal G. dos Remedios. Tissue Microarrays: Methods and Protocols. (2011) Proteomics; 11: 3436 (Issue 16)
James Erle Wolfe, Shin’ichi Ishiwata, Filip Braet, Renee Whan, Yingying Su, Cristobal G. dos Remedios and Sean Lal. SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation. (2011) Biophysical Reviews; 3; 53-62
Cristobal G Dos Remedios, James E Robinson, Renee Whan, Filip Braet, Yingying Su, Theresia Kraft, Jolanda van der Velden, Steven B Marston, Marja Steenman, Peter S Macdonald, Sean Lal. Quantifying the contractile performance of human cardiomyocytes. (2011) Biophysical Journal 100 (3) 298a
S. Lal, L. Nguyen, F. Ponten, J. Odeberg, C. Remedios. Tissue microarray profiling of four-and-a-half LIM protein in human heart failure. (2012) Heart Lung and Circulation 21, S97
Li, A., Estigoy, C., Raftery, M., Odeberg, J., Ponten, F., Lal, S., dos Remedios, C. How to use public resources in heart research: Human protein atlas and the Sydney heart bank. (2013) Heart Lung and Circulation 22 (10), 819-826
Tamara T. Koopmann1, Michiel E. Adriaens, Perry D. Moerland, Roos F. Marsman, Margriet L. Westerveld, Sean Lal, Taifang Zhang, Christine Q. Simmons, Istvan Baczko, Cristobal dos Remedios, Nanette H. Bishopric, Andras Varro, Alfred L. George, Jr., Elisabeth M. Lodder, Connie R. Bezzina. Genome- wide identification of expression quantitative trait loci (eQTLs) in human heart. (2014) PlosOne 9(5): e97380
Zijun Ge, Sean Lal, Loan Le, James Chong. Cardiac stem cells: translation to human studies. (2014) Biophysical Reviews 12/2014.
Belinda Gray, Paul Bannon, Brian Bailey, Sean Lal, Laura Yeates, David Richmond, Michael Byrom, Christopher Semsarian, Caroline Medi. A surgical myectomy program to manage complex obstructive hypertrophic cardiomyopathy. (2015) Heart, Lung and Circulation 24(3): S175
Sean Lal, Amy Li, David Allen, Paul Allen, Paul Bannon, Tim Cartmill, Roger Cooke, Alan Farnsworth, Anne Keogh and Cristobal dos Remedios. Best practice bio-banking of human heart tissue. (2015) Biophysical Reviews Dec 7(4): 399- 406.
Sean Lal, Amy Li and Cris dos Remedios. Limitations in translating animal studies to humans in cardiovascular disease. (2016) Journal of Cardiovascular Translational Research April 9(2): 165-6
James McNamara, Amy Li, Nicola Smith, Sean Lal, Bob Graham, KB Kooiker, Jenny Van Diik, Cris dos Remedios, Samantha Harris and Roger Cooke. Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes. (2016) Journal of Molecular and Cellular Cardiology March 26(94): 65-71
Sean Lal, Lisa Nguyen, Rhenan Tezone, Fredrik Ponten, Jacob Odeberg, Amy Li and Cristobal dos Remedios. Tissue MicroArray (TMA) Profiling in Human Heart Failure. (2016) Proteomics September 16(17): 2319-26.
Sean Lal, Lisa Turner, Catherine Powell, Michael Wilson and Paul Bannon. Improvements in Left Ventricular Ejection Fraction and Quality of Life in Patients with Heart Failure who undergo Coronary Artery Bypass Surgery. (2016) International Journal of Cardiology Volume 222 (1), Pages 671–673
Nelson Wang and Sean Lal. Post-dilation in Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-analysis. (2017) Journal of Interventional Cardiology Mar 21
Crossman DJ, Shen X, Jüllig M, Munro M, Hou Y, Middleditch M, Shrestha D, Li A, Lal S, Dos Remedios CG, Baddeley D, Ruygrok PN, Soeller C. Increased collagen within the transverse tubules in human heart failure. (2017) Cardiovasc Research. 2017 Apr 20
McNamara JW, Li A, Lal S, Bos JM, Harris SP, van der Velden J, Ackerman MJ, Cooke R, Dos Remedios CG. MYBPC3 Mutations are associated with a reduced Super-relaxed State in patients with Hypertrophic Cardiomyopathy. (2017) PLoS One Jun 28; 12(6): e0180064
C. G. dos Remedios, S. P. Lal, A. Li, J. McNamara, A. Keogh, P. S. Macdonald, R. Cooke, E. Ehler, R. Knöll, S. B. Marston, J. Stelzer, H. Granzier, C. Bezzina, van Dijk, F. De Man, G. J. M. Stienen, J. Odeberg, F. Pontén, W. Linke, J. van Velden. The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease. (2017) Biophysical Reviews 14th August
Jim Ge and Sean Lal. Human Cardiac Regeneration: New Cells in Old Hearts Revisited. (2017) Cardiology Today 2017; 7(2): 17-19
Ranganath Mamidi, Jiayang Li, Kenneth S. Gresham, Chang Yoon Doh, Amy Li, Sean Lal, Cristobal G. dos Remedios and Julian E. Stelzer. Dose-dependent effects of the myosin activator omecamtiv mecarbil on cross-bridge behavior and force generation in failing human myocardium. (2017) Circulation Heart Failure Oct; 10(10) 1-11
Nelson Wang, Jordan Fulcher, Nishan Abeysuryia, Mark Adams, Sean Lal. Predictors of Successful Chronic Total Occlusion Percutaneous Coronary Interventions: A systematic review and meta-analysis. (2017) British Medical Journal Heart Oct 6. pii: heartjnl-2017-311986
Sean Lal, Irina Kotchetikova, Jacob Cao, Daniel Jackson, Rachael Cordina and David S Celermajer. Heart failure admissions and poor subsequent outcomes in adults with congenital heart disease. (2017) European Journal of Heart Failure Apr;20(4):812-815.
Petr Vikhorev, Natalia Smoktunowicz, Alex Munster, O’Neal Copeland. Sawa Kostin, Cecile Montgiraudi, Andrew Messer, Mohammad Toliat, Amy Li, Cristoboal dose Remedios, Sean Lal, Cheavar Blair, Kenneth Campbell, Maya Guglin, Ralph Lnoll, Steven Marston. Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes. (2017) Scientific Reports Nov 1;7(1):14829
Jacob Cao, S Yee, Kevin Pham, David Celermajer, Sean Lal. Renin-angiotensin- aldosterone inhibition improves right ventricular function: a meta-analysis. (2018) Heart Asia. 2018 May 3;10(1)
Sean Lal. Cardiovascular Risk in Primary Sjrogen’s Syndrome. (2018) New England Journal of Medicine Jul 5; 379(1): 96-7
Richard Bagnall, Jodie Ingles, Marcel E. Dinger, Mark J. Cowley, Samantha Barratt Ross, André E. Minoche, Sean Lal, Christian Turner, Alison Colley, Sulekha Rajagopalan, Yemima Berman, Anne Ronan, Diane Fatkin, Christopher Semsarian. Whole Genome Sequencing improves outcomes in patients with hypertrophic cardiomyopathy. (2018) Journal of the American College of Cardiology 72 (4) 419-429.
Nelson Wang, Jordan Fulcher, Nishan Abeysuriya, Michele McGrady, Ian Wilcox, David Celermajer, Sean Lal. Tricuspid Regurgitation is associated with increased mortality independent of pulmonary pressures and right heart failure. (2019) European Heart Journal 40, 476-484. This article was editorialised European Heart Journal (2019) 40, 485–487.
Li A, Lal S, Dos Remedios CG. A step towards understanding the molecular nature of human heart failure: advances using the Sydney Heart Bank collection. (2019) Biophys Rev. Apr; 11(2):241-244.
Jacob Cao, Yen Chin Koay, Lake-Ee Quek, Benjamin Parker, Sean Lal*, John O’Sullivan* (*co-senior authors). Myocardial Metabolic Perturbations in Advanced Ischemic and Non-Ischemic Dilated Human Heart Failure. (2019) European Journal of Heart Failure. 21(8), 1042-1045.
Sean Lal and Bernhard Kuhn. Regenerating hearts by arresting development with hypothyroidism. (2019) Circulation Research. 124:1725-1726.
Jim Ge, Amy Li, James McNamara, Cris dos Remedios, Sean Lal. Pathogenesis and pathophysiology of heart failure with reduced ejection fraction: translation to human studies. (2019) Heart Failure Reviews. 24(5), 743-758.
Chenghao Liu, Seok Ting Lim, Weihua Song, Melissa Hui Yen Teo, Michelle Si Ying Tan, Madhura Dattatraya Kulkarni, Beiying Qiu, Amy Li, Sean Lal, Cristobal G. dos Remedios, Nguan Soon Tan, Walter Wahli, Michael Alan Ferenczi, Wanjin Hong, Xiaomeng Wang. Collaborative regulation of LRG1 by TGFβ1 and PPARβ/δ modulates chronic pressure-overload-induced cardiac fibrosis. (2019) Circulation Heart Failure Dec;12 (12): e005962.
Jacob Cao, John O’Sullivan, Sean Lal. Pathophysiology of heart failure with reduced ejection fraction. (2019) Book chapter (in press): Heart failure, an Essential Clinical Guide (Taylor and Francis publishers)
Moonen A, Lal S, Ingles J, Yeates L, Semsarian C, Puranik R. Prevalence of Anderson-Fabry disease in a cohort with unexplained late gadolinium enhancement on cardiac MRI. (2019) International Journal of Cardiology S0167- 5273 (19) 34325-6.
Nelson Wang, Jordan Fulcher, Nishan Abeysuriya, Laura Park, Shejil Kumar, Gian Luca Di Tanna, Ian Wilcox, Anthony Keech, Anthony Rodgers, Sean Lal. More intensive LDL-C lowering reduces major vascular events beyond current recommendations: systematic review and meta-analysis of 327,037 patients from cholesterol lowering randomised controlled trials. (2020) The Lancet Diabetes and Endocrinology 8 (1): 36-49 Editorialised The Lancet Diabetes and Endocrinology (2020) 8 (1): 5-7 This paper won the RPA Patrons Prize 2019 and the CSANZ Clinical Prize 2019
Nelson Wang, Ian Wilcox, Sean Lal. Invited Editorial – Lowering LDL cholesterol. (2020) Ageing Feb 19;12(4):3119-3120
Mark Dennis, Sean Lal, Paul Forrest, Alistair Nichol, Lionel Lamhaut, Richard Totaro, Brian Burns, Claudio Sandroni. Extracorporeal cardiopulmonary resuscitation in adult out of hospital cardiac arrest: A contemporary review. (2020) Journal of the American Heart Association. May 18;9(10): e016521
Mengbo Li, Benjamin L. Parker, Evangeline Pearson, Benjamin Hunter, Jacob Cao, Yen Chin Koay, Oneka Guneratne, David E. James, Jean Yang, Sean Lal*, John O’Sullivan* (*co-senior authors). Core functional nodes and sex-specific pathways in human ischaemic and dilated cardiomyopathy. (2020) Nature Communications June 2; 11 (2843).
Sean Lal, Christopher Hayward, Carmine De Pasquale, David Kaye, George Javorsky, Peter Bergin, Marcus Ilton, Robert Weintraub, John Atherton, Priya Nair, Mate Rudas, Lawrence Dembo, Robert Doughty, Paul Bannon, Nicole Bart, Clara Chow, Jo-Dee Lattimore, Leonard Kritharides, Richard Totaro, Peter Macdonald. COVID-19 and acute heart failure: screening the critically ill. (2020) National Position Statement for Australia and New Zealand; simultaneously published in Heart Lung and Circulation May 1: S1443-9506(20)30133-5
Trisha Tucholski, Wenxuan Cai, Zachery R. Gregorich, Elizabeth F. Bayne, Stanford D. Mitchell, Sean J. McIlwain, Willem J. De Lange, Max Wrobbel, Hannah Karp, Zachary Hite, Petr G. Vikhorev, Steve B. Marston, Sean Lal, Amy Li, Cristobal dos Remedios, Takushi Kohmoto, Joshua Hermsen, J. Carter Ralphe, Timothy J. Kamp, Richard L. Moss, Ying Ge. Converging Sarcomeric Proteoform Phenotypes in Human Hypertrophic Cardiomyopathy Revealed by Top-down Proteomics. (2020) Proceedings of the National Academy of Sciences (PNAS) Oct 6;117(40):24691-24700.
Farrah Othman, Maxwell Fulton, Sean Lal. What is diabetic cardiomyopathy? (2020) Medicine Today and Cardiology Today October 10:2 66-73
Nelson Wang, Jacob Cao, Sean Lal. Invited Editorial – COVID-19 Getting to the Heart of the Matter. (2020) European Journal of Heart Failure 22, 2216-2218
Petr G. Vikhorev, Natalia N. Vikhoreva, WaiChun Yeung, Amy Li, Sean Lal, Cristobal G. dos Remedios, Cheavar A. Blair, Maya Guglin, Kenneth S. Campbell, Magdi H. Yacoub, Pieter de Tombe, Steven B. Marston. Titin- truncating mutations associated with dilated cardiomyopathy alter length- dependent activation and its modulation via phosphorylation. (2020) Cardiovascular Research Nov 2:316.
Martin Ezeani, Christoph Hagemeyer, Sean Lal, Be’eri Niego. Molecular Imaging of Atrial Myopathy: Towards Early AF detection and Non-invasive Disease Management. (2020) Trends in Cardiovascular Medicine Dec 15: S1050- 1738(20)30155-9
Jessie W Yester, Honghai Liu, Frank Gyngard, Niyatie Ammanamanchi, Kathryn C Little, Dawn Thomas, Mara L. G. Sullivan, Sean Lal, Matthew L Steinhauser, Bernhard Kühn. Use of stable isotope-tagged thymidine and multi-isotope imaging mass spectrometry (MIMS) for prospective quantification of human cardiomyocyte division. (2021) Nature Protocols Feb 24 1995-2022
Mira Holliday, Emma S. Singer, Samantha B. Ross, Seakcheng Lim, Sean Lal, Jodie Ingles, Christopher Semsarian, Richard D. Bagnall. Transcriptome sequencing of patients with hypertrophic cardiomyopathy reveals MYBPC3 variants amenable to antisense oligonucleotide therapy. (2021) Circulation Genomics and Precision Medicine Apr;14(2): e003202
Choon Boon Sim, Belinda Phipson, Mark Ziemann, Haloom Rafehi, Richard J. Mills, Kevin I. Watt, Kwaku D. Abu-Bonsrah, Ravi K.R. Kalathur, Holly K. Voges, Doan T. Dinh, Menno ter Huurne, Celine J. Vivien, Antony Kaspi, Harikrishnan Kaipanaickal, Alejandro Hidalgo, Leanne M.D. Delbridge, Rebecca L. Robker, Paul Gregorevic, Cristobal G. dos Remedios, Sean Lal, Adam T. Piers, Igor E. Konstantinov, David A. Elliott1, Assam El-Osta, Alicia Oshlack, James E. Hudson, Enzo R. Porrello. Sex-specific control of human heart maturation by the progesterone receptor. (2021) Circulation Apr 20;143(16):1614-1628.
Gabby Fusco, Desmond Li, Benjamin Hunter, Dan Jackson, Paul Bannon, Sean Lal and John O’Sullivan. Optimizing the Discovery and Assessment of Therapeutic Targets in Heart Failure with Preserved Ejection Fraction. (2021). ESC Heart Failure Oct;8(5):3643-3655.
Shannon Chiang, Nady Braidy, Sanaz Maleki, Sean Lal, Des Richardson, Michael Huang. Mechanisms of impaired mitochondrial homeostasis and NAD metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation. (2021) Redox Biology Oct; 46:102038.
Shashwati Dutta*, Desmond Li*, Andy Wang, Mark Ishak, Kristina Cook, Melissa Farnham, Hasthi Dissanayake, Peter Cistulli, Imre Hunyor, Renping Liu, Ian Wilcox, Yen Chin Koay, Jean Yang, Sean Lal, John F. O’Sullivan. Metabolite signatures of cardiac remodeling, heart failure, sleep apnoea, their interaction, and outcomes in the community (2021). ESC Heart Failure Oct;8(5):3643-3655.
Hou Y, Bai J, Shen X, de Langen O, Li A, Lal S, Dos Remedios CG, Baddeley D, Ruygrok PN, Soeller C, Crossman DJ. Nanoscale organisation of ryanodine receptors and junctophilin-2 in the failing human heart (2021). Fron Physiology Oct 8; 12:724372
Paraskevi Morris, Sean Lal, Shisan Bao, Mark Dennis, Imre Hunyor, John O’Sullivan, Stuart Grieve, Rajesh Puranik. Relationship of myocardial gadolinium enhancement to late clinical outcomes: implications for the COVID-19 era (2021). Heart Lung and Circulation Nov 1: S1443-9506(21)01205-1
Zhu Yan, Dan Jackson, Benjamin Hunter, Lorna Beattie, Lisa Turner, Brett Hambly, Richmond Jeremy, Cassandra Malecki, Elizabeth Robertson, Amy Li, Cris dos Remedios, David Richmond, Christopher Semsarian, John O’Sullivan, Paul Bannon, Sean Lal. Models of Cardiovascular Surgery Biobanking to Facilitate Translational Research and Precision Medicine (2022). ESC Heart Failure. Feb;9(1):21-30.
Jacob Cao, John O’Sullivan, Sean Lal. Pathophysiology of heart failure with reduced ejection fraction. Book Chapter in the textbook titled: Heart Failure (2022) 1st Edition Taylor & Francis publishing.
Mark Dennis, Sashie Howpage, Shashwati Dutta, Yen Koay, Lisa Nguyen Lal, Sean Lal, Ted Wu, Phillip Munoz, Stephen Twigg, John O’Sullivan, Rajesh Puranik. Myocardial fibrosis in Type 2 Diabetes, detected by cardiovascular magnetic resonance is associated with functional and metabolomic parameters (2022). International Journal of Cardiology Sep 15;363:179-184.
Nelson Wang, Jack Evans, Sonia Sawant, James Sindone, Sean Lal. Sex differences in the efficacy of heart failure therapies. (2022). Heart Failure Reviews (in press)
James W. McNamara, Benjamin L. Parker, Holly K. Voges, Neda R. Mehdiabadi, Francesca Bolk, Feroz Ahmad, Jin D. Chung, Natalie Charitakis, Jeffrey Molendijk, Antonia T.L. Zech, Sean Lal, Mirana Ramialison, Kathy Karavendzas, Hayley L. Pointer, Petros Syrris, Luis R. Lopes, Perry M. Elliott, Gordon S. Lynch, Richard J. Mills, James E. Hudson, Kevin I. Watt, Enzo R. Porrello, David A Elliott. Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle. (2023) Nature Cardiovascular Research 2 159–173
Emma S. Singer, Joshua Crowe, Mira Holliday, Julia C. Isbister, Sean Lal, Natalie Nowak, Laura Yeates, Charlotte Burns, Sulekha Rajagopalan, Ivan Macciocca, Ingrid King, Julie Wacker, Jodie Ingles, Robert G Weintraub, Christopher Semsarian, Richard D. Bagnall. The burden of splice-disrupting variants in inherited heart disease and sudden unexplained death. (2023) Nature Genomics Medicine 8:1(29)
Jude Taylor, Anna C. Y. Yeung, Anthony Ashton, Alen Faiz, Victor
Guryev, Bernard Fang, Sean Lal, Mark Grosser, Cristobal G Dos Remedios, Filip Braet, Craig S McLachlan, Amy Li. Transcriptomic comparison of human peripartum and dilated cardiomyopathy identifies differences in key disease pathways. (2023) Journal of Cardiovascular Development and Disease 10:188
Nelson Wang and Sean Lal. The importance of tricuspid regurgitation – time to move on. (2023). Invited Editorial. Circulation Cardiovascular Imaging Jul;16(7):577-579
Varun Sharma, Alex Green, Aaron McLean, John Adegoke, Claire Gordon, Graham Starkey, Rohit D’Costa, Fiona James, Isaac Afara, Sean Lal, Bayden Wood, Jaishankar Raman. Towards a point-of-care multimodal spectroscopy instrument for the evaluation of human cardiac tissue. (2023) Heart and Vessels Dec 38(12): 1476-1485
Sean Lal, Ken Campbell, Amy Li. Molecular and cellular mechanisms of heart failure: pathophysiology, pathogenesis, and therapeutics. (2023) Invited Editorial. Frontiers Cardiovascular Medicine 10:1260483.
Amy Li, Gerald Shami, Lisa Griffiths, Sean Lal, Helen Irving, Filip Braet. Giant mitochondria in cardiomyocytes: cellular architecture in health and disease. (2023). Basic Research in Cardiology 118 (1), 39
Valentin Burkart, Kathrin Kowalski, Alina Disch, Denise Hilfiker-Kleiner, Sean Lal, Cristobal dos Remedios, Andreas Perrot, Andre Zeug, Evgeni Ponimaskin, Maike Kosanke, Oliver Dittrich-Breiholz, Theresia Kraft, Judith Montag. Nonsense mediated decay factor UPF3B is associated with cMyBP-C haploinsufficiency in hypertrophic cardiomyopathy patients. (2023) Journal of Molecular and Cellular Cardiology 185, 26-37
Yen Chin Koay, Niv Vigder, Serlin Lauren, Angela Yu Bai, Saki Tomita, Desmond Li, Ren Ping Liu, Dylan Harvey, Benjamin Hunter, Jean Yang, Paul Bannon, Ashleigh Philp, Andrew Philp, Mark Larance, Sean Lal*, John F. O’Sullivan*. (*co-senior authors). The efficacy of risk factor modification compared to NAD repletion in diastolic heart failure. (2024) Journal of the American College of Cardiology: Basic to Translational Science (in press)
Hayden McColl, Rachael Cordina, Sean Lal, Matthew Parker, Imre Hunyor, Caroline Medi, Belinda Gray, Recurrent immunosuppressive-responsive myocarditis in a patient with desmoplakin cardiomyopathy: a case report. (2024) European Heart Journal – Case Reports, Volume 8, Issue 3, March 2024
Nelson Wang, Phidias Rueter, Melvin Ng, Sashiruben Chandramohan, Thomas Hibbert, John F. O’Sullivan, David Kaye, Sean Lal. Echocardiographic predictors of cardiovascular outcome in heart failure with preserved ejection fraction. (2024) European Journal of Heart Failure (in press).
Matthew Taper, Glenn Carrington, Michelle Peckham, Sean Lal*, Robert Hume* (co-senior authors). Comparison of Immunofluorescence and immunohistochemistry protocols for Improved reproducibility and signal in human left ventricle cardiac tissue. (2024) Journal of Microscopy (in press)