Profile
Prof Ian Wilcox
- Cardiologist, Royal Prince Alfred Hospital (Senior VMO)
- Clinical Professor, Sydney Medical School, University of Sydney
- Cardiologist, Strathfield Private Hospital
- Consultant Cardiologist, Chris O'Brien Lifehouse
Professor Ian Wilcox has a career-long interest in clinical research, teaching and clinical practice in Cardiology.
Founder and Lead Cardiologist at Central Sydney Cardiology which specialises in patient-centric, personalised Medicine in chronic and complex heart and aortic disease.
Trained as a Research Cardiologist in Predicting Risk in Acute Coronary Syndromes he was one of the first Cardiologists in the World to link Sleep Apnoea with Heart Disease and defined the links between OSA and Metabolic Syndrome (Syndrome Z) working with Professor Colin Sullivan who invented CPAP. His research is widely cited (over 6000 citations) and impactful (Google Scholar i10 46).
Since founding CSC in 1999 the Practice has developed a national and international reputation for rapidly translating rigorous research into clinical practice.
Areas of special interest include complex acute and chronic heart disease including Familial Heart Disease, Asymptomatic Coronary Disease, Heart Failure across the Spectrum, Advanced Echocardiography including Cardio-oncology, novel imaging analysis (CaRi-Heart®, Caristo Diagnostics), Remote monitoring of implanted cardiac devices and CPAP therapy.
Organisational and leadership achievements include Founding Central Sydney Cardiology — Australia’s only Academic Cardiology Practice, Co-founder of the Cardiovascular Program at Strathfield in 1991 and building deeper Academic and Teaching linkages with the Faculty of Medicine and Health, Sydney University. Board Member of the ResMed Foundation.
- Complex adult heart disease including asymptomatic coronary (ASCVD), acute coronary disease, valvular disease, cardiomyopathy, cardiac arrhythmias and inherited and familial heart disease including Lipoprotein(a), Familial Hypercholesterolaemia.
- Advanced and Novel Cardiac imaging including 3D echo and strain imaging, novel stress echocardiography.
- Newer Coronary Imaging (Photon Counting CTCA or PCCT), AI-enabled imaging analysis (CaRi-Heart®, Caristo.com). Advanced Cross-sectional Imaging Software (3mensio Medical Imaging B.V.).
Selected Publications:
Metabolite signatures of heart failure, sleep apnoea, their interaction, and outcomes in the community. Shashwati Dutta*, Desmond Li*, Andy Wang, Mark Ishak, Kristina Cook, Melissa Farnham, Hasthi Dissanayake, Peter Cistulli, Imre Hunyor, Renping Liu, Ian Wilcox, Yen Chin Koay, Jean Yang, Sean Lal, John F. O’Sullivan. ESC Heart Failure (accepted 12/09/2021)
A Leadless Intracardiac Transcatheter Pacing System. Chan KH, McGrady M, Wilcox I. N Engl J Med. 2016 Jun 30;374(26):2604. doi: 10.1056/NEJMc1604852#SA1.
Wilcox I, Chan KH, Dimitri H. Diagnosis and treatment of obstructive sleep apnea is key to achieving optimal results after catheter ablation of atrial fibrillation. J Am Coll Cardiol. 2014;63(6):607-8.
Fulcher J, Wilcox I. Basal stress cardiomyopathy induced by exogenous catecholamines in younger adults. Int J Cardiol. 2013;168(6):158-60.
Arnott C, Wilcox I, Patel S. A Case of ST Elevation Myocardial Infarction Secondary to Heparin-induced Thrombocytopaenia with Thrombosis. Heart Lung Circ. 2012 Dec;21(12):841-3
Wilcox I, Chan KH, Lattimore JD. Hypoxia and inflammation. N Engl J Med. 2011;364(20):1976-7
Chan KH, Wilcox I. Obstructive Sleep Apnea: a Novel Trigger for Cardiac Arrhythmias and Potential Therapeutic Target. Expert Review of Cardiovascular Therapy 20108(7):981-94
Wilcox I, Semsarian C. Obstructive sleep apnea: a respiratory syndrome with protean cardiovascular manifestations. (Editorial) Journal of the American College of Cardiology 2009;54:1810-11
Lattimore JD, Wilcox I, Adams MR, Kilian JG, Celermajer DS. Treatment of obstructive sleep apnoea leads to enhanced pulmonary vascular nitric oxide release. Int J Cardiol. 2008;126(2):229-33.
Lattimore J.D., Wilcox I, Skilton M, Langenfeld M, Celermajer DS. Treatment of obstructive sleep apnoea leads to improved microvascular endothelial function in the systemic circulation. Thorax. 2006 Jun;61(6):491-5. Epub 2006 Mar 14
Wilcox I, Booth V, Lattimore JD. Sleep apnea and heart disease. N Engl J Med. 2006 ; 354(10):1086-9
Lattimore J-D, Celermajer D.S, Wilcox I. Sleep Apnea and Cardiovascular Disease. Journal of the American College of Cardiology 2003;41:1429-37
Wilcox I, McNamara SG, Sullivan CE. Central sleep apnea and heart failure. N Engl J Med 2000;342:293
Wilcox I, McNamara SG, Collins FL, Grunstein RR, Sullivan CE ‘Syndrome Z’: The Interaction of Sleep Apnoea, Vascular Risk Factors and Heart Disease. Thorax 1998;53 (suppl 3) S12:S25-28
Wilcox I, McNamara SG, Dodd MJ, Sullivan CE. Ventilatory control in patients with sleep apnoea and left ventricular dysfunction: comparison of obstructive and central sleep apnoea. European Respiratory Journal 1998;11:7-13 [Editorial: Augmented chemosensitivity to hypercapnia: another link in our understanding of the pathogenesis of Cheyne-Stokes respiration. Hanly P. pp3-4]
Wilcox I, Grunstein RR., Hedner JA., Doyle J, Collins FL, Fletcher PJ, Kelly DT, Sullivan CE. Effect of nasal continuous positive airway pressure during sleep on 24-hour blood pressure in obstructive sleep apnea. Sleep 1993;16:539-45
Wilcox I, Grunstein RR, Collins FL, Doyle J, Kelly DT, Sullivan CE. Circadian variation in blood pressure in obstructive sleep apnea. Blood Pressure 1992;1:219-222
Wilcox I, Freedman SB, Allman KC, Collins FL, Leitch JW, Kelly DT, Harris PJ. The prognostic significance of a pre-discharge exercise test in risk stratification after unstable angina pectoris. Journal of theAmericanCollege of Cardiology 1991;18:677-83 [Editorial: Vagaries of predischarge exercise stress testing in acute myocardial ischemic syndromes. Ferlinz J. pp 684-6]
Wilcox I, Freedman SB, McCredie RJ, Carter GS, Kelly DT, Harris PJ. Risk of adverse outcome in patients admitted to the coronary care unit with suspected unstable angina. American Journal of Cardiology 1989;64:845‑848