Profile
Prof John O’Sullivan
- Professor of Cardiometabolic Medicine, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney
- Clinical-Academic Cardiologist, Royal Prince Alfred Hospital
- Director, Heart Failure Alliance
- Director, HFpEF Clinic, Royal Prince Alfred Hospital
- Professor of Medicine, TU Dresden, Germany
Professor O’ Sullivan is the Inaugural Professor of Cardiometabolic Medicine at The University of Sydney, a Clinical-Academic Cardiologist at Royal Prince Alfred Hospital, and Cardiologist at Central Sydney Cardiology.
Professor O’Sullivan in an Internationally trained Cardiologist who completed Medicine in Ireland followed by Advanced clinical and scientific training in Cardiology in the USA at the Massachusetts General Hospital, Harvard Medical School and the Massachusetts Institute of Technology (MIT).
His clinical interests are in complex and chronic heart disease with a focus on the common, but previously neglected, condition of Heart Failure with Preserved Ejection Fraction (HFpEF).
A major underlying cause of this type of heart failure is a profound disturbance energetic machinery (‘Cardiometabolism’) of the heart, and new discoveries in this realm have fundamentally changed our understanding of this disabling and life-threatening condition.
Professor O’Sullivan has led groundbreaking discoveries in the field of heart failure energy generation, and has translated this work to clinical trials.
His research program is located in the Cardiometabolic Laboratory at the Charles Perkins Centre, University of Sydney as well as important collaborations Nationally and Internationally (The Alfred Hospital and Monash University Hospital, Harvard, Dresden, Glasgow, University of Cambridge) and the Baird Institute, NSW Centre for Heart Failure & Diseases of the Aorta.
His ’Bench to Bedside’ research explores heart function in a myriad of ways including single cells, heart slices and intact human research at Royal Prince Alfred Hospital and the Alfred Hospital, Melbourne.
He founded a unique HFpEF Failure Clinic at Royal Prince Alfred Hospital where previously underserviced patients with this condition are managed with findings translated from world class research into contemporary practice.
He publishes in the highest impact journals, reviews for national/federal funding agencies globally, and is frequently invited to present at international meetings. He holds several institutional and professional leadership positions.
University of Sydney: https://www.sydney.edu.au/medicine-health/about/our-people/academic-staff/john-osullivan.html
Baird Institute: https://bairdinstitute.org.au/centre-for-heart-failure-diseases-of-the-aorta
- John has clinical and research interests in heart failure, particularly Heart Failure preserved Ejection Fraction (HFpEF), a type of heart failure that now accounts for more than half of all heart failure cases, but for which there are no treatments. He uses a range of tools to study this disease, including cardiac MRI.
- Employing new insights from his HFpEF research program, he aims to offer the most up-to-date, evidence-based therapeutic strategies to help patients with this disease.
- John is trained in advanced imaging including echocardiography and is Level III SCMR Certified in Cardiac MRI.
- John leads a stress haemodynamic imaging program at Central Sydney Cardiology and co-established an invasive exercise right heart catheterisation program at RPAH.
- John has a strong clinical interest in cardiometabolic disease: how unhealthy diet, overweight / obesity, and insulin resistance interact with cardiovascular disease, driving atherosclerosis and heart failure. He also studies the role of the microbiome in these diseases.
- Cardiovascular prevention, particularly how to employ the latest evidence in dietary science and exercise to prevent and manage cardiovascular disease, is a core focus of John’s clinical interests.
The heart has intrinsic ketogenic capacity that mediates NAD+ Therapy in HFpEF.
Yen Chin Koay, Bailey McIntosh, Yang Cao, Yann Huey Ng, Yanchuang Han, Saki Tomita, Angela Yu Bai, Benjamin Hunter, Ashish Misra, Christopher M. Loughrey, Paul G. Bannon, Sean Lal, Aldons J. Lusis, David M. Kaye, Mark Larance, JOHN F. O’SULLIVAN.
Circulation Research 2025 Apr 11;136(10):1113–1130. PMID: 40211954, PMCID: PMC12063684 https://doi.org/10.1161/CIRCRESAHA.124.325550
Editorialised: “Intrinsic Ketogenic Capacity of the Heart: Mechanisms and Therapeutic Potential”, Rosanna Caputo and Carolina Magdalen Greco
Circulation Research, Volume 136, Number 10
https://doi.org/10.1161/CIRCRESAHA.125.326560
Featured as Research Highlight “Ketogenic capacity of the heart determines the outcome of heart failure” in Nature Cardiovascular Research June 2025 https://doi.org/10.1038/s44161-025-00676-4.
Mechanical unloading is accompanied by reverse metabolic remodelling in the failing heart: identification of a novel citraconate pathway.
David M. Kaye, Xiao Suo Wang, Yen Chin Koay, Mengbo Li, Bailey McIntosh, Yann Huey Ng, Michael Rahman, Yiyang Cao, Francine Z. Marques, Cassandra Malecki, Shane Nanayakkara, Justin Mariani, Bing Wang, Sean Lal, Giovanni Guglielmi, JOHN F. O’SULLIVAN.
European Journal of Heart Failure 4 June 2025. https://doi.org/10.1002/ejhf.3704
Multi-organ multi-omic and gut microbiome markers of fat and sucrose dietary oversupply in cardiometabolic disease.
Ren Ping Liu, Alistair Senior, Zhen Bao, Yen Chin Koay, Andrew Holmes, JOHN F. O’SULLIVAN.
iScience Volume 28, Issue 4, 18 April 2025. https://doi.org/10.1016/j.isci.2025.111887gq
Myocardial post-transcriptional landscape in peripartum cardiomyopathy.
Amy Li*, Bernard Fang*, Mengbo Li*, Yen Koay, Cassandra Malecki, Benjamin Hunter, Dylan Harney, Cris dos Remedios, Mark Larance, JOHN F. O’SULLIVAN#, Sean Lal#.
*Joint senior author
Circulation: Heart Failure 2024 Dec;17(12):e011725. https://doi.org/10.1161/CIRCHEARTFAILURE.124.011725
Leveraging metabolism for better outcomes in heart failure.
Yann Huey Ng, Yen Chin Koay, Francine Z Marques, David M Kaye, JOHN F. O’SULLIVAN.
Cardiovascular Research 2024. 2024 Oct 1:cvae216. doi: 10.1093/cvr/cvae216. PMID: 39351766.
The efficacy of risk factor modification compared to NAD+ repletion in diastolic heart failure.
Yen Chin Koay, Ren Ping Liu, Bailey McIntosh, Niv Vigder, Serlin Lauren, Angela Yu Bai, Saki Tomita, Desmond Li, Dylan Harney, Benjamin Hunter, Yunwei Zhang, Jean Yang, Paul Bannon, Ashleigh Philp, Andrew Philp, David M. Kaye, Mark Larance, Sean Lal, JOHN F. O’SULLIVAN.
JACC: Basic to translational research 2024 Mar 20;9(6):733-750. doi: 10.1016/j.jacbts.2024.01.011. PMID: 39070276 PMCID: PMC11282886 DOI: 10.1016/j.jacbts.2024.01.011
Editorialised: Coordinate Targeting of Mitochondrial Energetics, Antioxidant Defenses, and Inflammation: Is NAD+ Boosting an HFpEF Elixir?
Michael N Sack
J Am Coll Cardiol Basic Trans Science. 2024 Jun, 9 (6) 751–753, PMID: 39070278, PMCID: PMC11282880, DOI: 10.1016/j.jacbts.2024.02.013.
Cardiac Substrate Utilization and Relationship to Invasive Exercise Hemodynamic Parameters in HFpEF.
JOHN F. O’SULLIVAN, Mengbo Li, Yen Chin Koay, Xiao Suo Wang, Giovanni Guglielmi, Francine Z. Marques, Shane Nanayakkara, Justin Mariani, Eugene Slaughter, and David M. Kaye.
JACC: Basic to translational research. 2024 Mar, 9 (3) 281–299. https://doi.org/10.1016/j.jacbts.2023.11.006. PMID: 38559626
Editorialised: “The Farm to Table HFpEF Kitchen”, JACC BTS 2024 Mar, 9 (3) 300–302. PMID: 38559628.
Indole-3-Propionic Acid Protects against Heart Failure with Preserved Ejection Fraction (HFpEF).
Yang Cao, Yu-Chen Wang, Yen Chin Koay, Calvin Pan, Zhiqiang Zhou, Sarada Charugundla, W. H. Tang, Jennifer Wilcox, Xinmin Li, Alexia Zagouras, Francine Marques, Hooman Allayee, David Kaye, JOHN O’SULLIVAN, Stanley Hazen, and Aldons Lusis.
Circulation Research. 2024 Feb 16;134(4):371-389. doi: 10.1161/CIRCRESAHA.123.322381. Epub 2024 Jan 24. PMID: 38264909 PMCID: PMC10923103.
Echocardiographic predictors of cardiovascular outcome in heart failure with preserved ejection fraction.
Nelson Wang, Phidias Rueter, Melvin Ng, Sashiruben Chandramohan, Thomas Hibbert, JOHN F. O’SULLIVAN, David Kaye, Sean Lal.
European Journal of Heart Failure 2024 May 7. doi: 10.1002/ejhf.3271. PMID: 38714362. DOI: 10.1002/ejhf.3271.
The First Human Normative Ranges and Biomarker Performance of Dimethylguanidino Valeric Acid Isoforms in Fatty Liver Disease.
Sami Qadri, XiaoSuo Wang, Collin Tran, Michael Fitzpatrick, Paul Bonnitcha, David Sullivan, Hannele Yki-Järvinen, JOHN F. O’SULLIVAN.
Pathology 2023 Nov 23:S0031-3025(23)00296-9. PMID: 38071157. DOI: 10.1016/j.pathol.2023.10.006
Preventing sheep carotid artery spasm for vascular graft surgery and computed tomography angiography.
Z Wang, H Paterson, L Pater, I Wise, M Adams, D Ng, R Qasabian, JOHN O’SULLIVAN, Sean Lal, A Weiss, P Bannon, RD Hume.
Tissue Engineering Part C: Methods 30 (8), 335-342, 2024.
Ventricle-specific myocardial protein and metabolite characterisation in healthy humans, with differential regulation in end-stage cardiomyopathies.
Hunter, B., Li, M., Parker, B., Koay, Y., Harney, D., Pearson, E., Cao, J., Chen, G., Guneratne, O., O’SULLIVAN, J. (2024).
Rapid benefits in older age from transition to whole food diet regardless of protein source or fat to carbohydrate ratio: A randomized control trial.
RV Ribeiro, AM Senior, SJ Simpson, J Tan, D Raubenheimer, D Le Couteur, L Macia, A Holmes, J Eberhard, JOHN O’SULLIVAN, YC Koay, A Kanjrawi, J Yang, T Kim, A Gosby.
Aging Cell, 23 (11), e14276, 2024.
Proteomic and metabolomic analyses of the human adult myocardium reveal ventricle-specific regulation in end-stage cardiomyopathies.
Hunter, B., Li, M., Parker, B., Koay, Y., Harney, D., Pearson, E., Cao, J., Chen, G., Guneratne, O., Smyth, G., Larance, M., O’SULLIVAN, J.F.,*, Lal, S.*.
Co-senior author.
Communications Biology, 7(1), 1666 (2024), https://doi.org/10.1038/s42003-024-07306-y.
Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors: JACC State-of-the-Art Review.
Gemma A Figtree, Stephen T Vernon, Jason A Harmer, Michael P Gray, Clare Arnott, Eric Bachour, Giannie Barsha, David Brieger, Alex Brown, David S Celermajer, Keith M Channon, Nicholas WS Chew, James JH Chong, Clara K Chow, Peter A Cistulli, Patrick T Ellinor, Stuart M Grieve, Tomasz J Guzik, Emil Hagström, Alicia Jenkins, Garry Jennings, Anthony C Keech, Katharine A Kott, Leonard Kritharides, Mamas A Mamas, Roxana Mehran, Peter J Meikle, Pradeep Natarajan, Kazuaki Negishi, JOHN F. O’SULLIVAN, Sanjay Patel, Peter J Psaltis, Julie Redfern, Philippe G Steg, David R Sullivan, Johan Sundström, Birgit Vogel, Andrew Wilson, Dennis Wong, Deepak L Bhatt, Jason C Kovacic, Stephen J Nicholls.
J Am Coll Cardiol. 2023 Sep 26;82(13):1343-1359. doi: 10.1016/j.jacc.2023.06.045. PMID: 37730292 PMCID: PMC10522922 DOI: 10.1016/j.jacc.2023.06.045.
Lessons learnt in the first year of an Australian pediatric cardio oncology clinic.
Claudia Toro, Ben Felmingham, Mangesh Jhadav, David S Celermajer, Andre La Gerche, JOHN F. O’SULLIVAN, Sanjeev Kumar, Marion K Mateos, Joy Fulbright, Dinisha Govender, Lane Collier, Michael Cheung, David D Eisenstat, Peter W Lange, Julian Ayer, David A Elliott, Rachel Conyers.
Cardiooncology. 2023 Dec 7;9(1):45. doi: 10.1186/s40959-023-00194-x. PMID: 38062530 PMCID: PMC10702043.
Cardio-oncology recommendations for pediatric oncology patients: an Australian and New Zealand Delphi consensus.
Claudia Toro, Ben Felmingham, Sophie Jessop, David S Celermajer, Rishi S Kotecha, Dinisha Govender, Diane Marie Terese Hanna, Matthew O’Connor, Rebecca Manudhane, Julian Ayer, JOHN F. O’SULLIVAN, Michael Sullivan, Ben Costello, André La Gerche, Thomas Walwyn, Lisa Horvath, Marion K Mateos, Joy Fulbright, Mangesh Jadhav, Michael Cheung, David Eisenstat, David A Elliott, Rachel Conyers.
JACC Adv. 2022 Dec, 1 (5) 100155. https://doi.org/10.1016/j.jacadv.2022.100155.
Human hearts have an intrinsic regenerative potential following myocardial infarction.
Sean Lal, Robert Hume, Jessica Warwick, Woo Jun Shim, Cassandra Malecki, Mengbo Li, Dylan Harney, Eugene Slaughter, Xiaosuo Wang, Lisa Nguyen, Louise Cole, James Edelman, Fairooj Rashid, Callum Houlahan, Antony Gao, Angela Ferguson, James Chong, Mark Larance, JOHN F. O’SULLIVAN, Nathan Palpant, Paul Bannon.
Researchsquare 2023/9/7 https://doi.org/10.21203/rs.3.rs-3244463/v1
Metabolomics and Lipidomics Signatures of Insulin Resistance and Abdominal Fat Depots in People Living with Obesity.
Yen Chin Koay, Adelle C F Coster, Daniel L Chen, Brad Milner, Amani Batarseh, JOHN F. O’SULLIVAN*, Jerry R Greenfield*, Dorit Samocha-Bonet*
* = co-senior author
Metabolites 2022 Dec 15;12(12):1272. doi: 10.3390/metabo12121272. PMID: 36557310.
Intersection of Diet and Exercise with the Gut Microbiome and Circulating Metabolites in Male Bodybuilders: A Pilot Study.
Alison WS Luk, Lachlan Mitchell, Yen Chin Koay, JOHN F. O’SULLIVAN, Helen O’Connor, Daniel A Hackett, Andrew Holmes.
Metabolites 2022. 2022 Sep 27;12(10):911. doi: 10.3390/metabo12100911. PMID: 36295813.
Myocardial fibrosis in type 2 diabetes is associated with functional and metabolomic parameters.
Mark Dennis, Sashie Howpage, Margaret McGill, Shashwati Dutta, Yen Koay, Lisa Nguyen Lal, Sean Lal, Ted Wu, Martin Ugander, Alexandra Wang, Phillip A Munoz, Jencia Wong, Maria I Constantino, JOHN F. O’SULLIVAN, Stephen M Twigg, Rajesh Puranik.
Int J Cardiol. 2022 Jun 18;S0167-5273(22)00948-2. doi: 10.1016/j.ijcard.2022.06.049. PMID: 35724800.
Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling.
Roman N Rodionov, Natalia Jarzebska, Dmitrii Burdin, Vladimir Todorov, Jens Martens-Lobenhoffer, Anja Hofmann, Anne Kolouschek, Nada Cordasic, Johannes Jacobi, Elena Rubets, Henning Morawietz, JOHN F. O’SULLIVAN, Alexander G Markov, Stefan R Bornstein, Karl Hilgers, Renke Maas, Christian Pfluecke, YingJie Chen, Stefanie M Bode-Böger, Christian PM Hugo, Bernd Hohenstein, Norbert Weiss.
Sci Rep. 2022 Jun 7;12(1):9381. doi: 10.1038/s41598-022-13169-2. PMID: 35672381
Design and validation of an LC-MS/MS method for simultaneous quantification of asymmetric dimethylguanidino valeric acid, asymmetric dimethylarginine and symmetric dimethylarginine in human plasma.
Paul Bonnitcha, David Sullivan, Michael Fitzpatrick, Andrea Ireland, Van Long Nguyen, Yen Chin Koay, JOHN F. O’SULLIVAN.
Pathology, 29th April 2022. PMID: 35501169 DOI: 10.1016/j.pathol.2022.01.008
Multi-omics of a pre-clinical model of diabetic cardiomyopathy reveals increased fatty acid supply impacts mitochondrial metabolic selectivity.
Desmond K Li, Lauren E Smith, Alexander W Rookyard, Shivanjali J Lingam, Yen C Koay, Holly P McEwen, Stephen M Twigg, Anthony S Don, JOHN F. O’SULLIVAN, Stuart J Cordwell, Melanie Y White.
J Mol Cell Cardiol. 2021 Nov 24;164:92-109. doi: 10.1016/j.yjmcc.2021.11.009. PMID: 34826416.
Nicotinamide riboside supplementation does not alter whole‐body or skeletal muscle metabolic responses to a single bout of endurance exercise.
Ben Stocks, Stephen P Ashcroft, Sophie Joanisse, Linda C Dansereau, Yen Chin Koay, Yasir S Elhassan, Gareth G Lavery, Lake‐Ee Quek, JOHN F. O’SULLIVAN, Ashleigh M Philp, Gareth A Wallis, Andrew Philp.
J Physiol. 2021 Mar;599(5):1513-1531. PMID: 33492681 DOI: 10.1113/JP280825.
Metabolic Signatures in Coronary Artery Disease: Results from the BioHEART-CT Study.
Stephen T Vernon, Owen Tang, Taiyun Kim, Adam S Chan, Katharine A Kott, John Park, Thomas Hansen, Yen C Koay, Stuart M Grieve, JOHN F. O’SULLIVAN, Jean Y Yang, Gemma A Figtree.
Cells. 2021 Apr 22;10(5):980. PMID: 33922315 PMCID: PMC8145337 DOI: 10.3390/cells10050980.
Metabolite signatures of heart failure, sleep apnoea, their interaction, and outcomes in the community. Shashwati Dutta*, Desmond Li*, Andy Wang, Mark Ishak, Kristina Cook, Melissa Farnham, Hasthi Dissanayake, Peter Cistulli, Imre Hunyor, Renping Liu, Ian Wilcox, Yen Chin Koay, Jean Yang, Sean Lal, John F. O’Sullivan. ESC Heart Failure (accepted 12/09/2021)
Core Functional Nodes and Sex-Specific Pathways in Human Ischemic and Dilated Cardiomyopathy. Mengbo Li*, Benjamin L. Parker*, Evangeline Pearson, Benjamin Hunter, Jacob Cao, Yen Chin Koay, Oneka Guneratne, David E. James, Jean Yang, Sean Lal*, John F. O’Sullivan*. Nature Communications 2020 Jun 2;11(1):2843. PMID: 32487995. PMCID: PMC7266817.
hRUV: Hierarchical approach to removal of unwanted variation for large-scale metabolomics data Taiyun Kim^, Owen Tang^, Stephen T Vernon, Katharine A Kott, Yen Chin Koay, John Park, David James, Stuart M. Grieve, Terence P Speed, Pengyi Yang+, Gemma A Figtree+, John F. O’Sullivan+, Jean Yee Hwa Yang+. +joint senior authors Nature Communications 2, 4992 (2021). https://doi.org/10.1038/s41467-021-25210-5
Optimising the Discovery and Assessment of Therapeutic Targets in Heart Failure with preserved Ejection Fraction. Gabrielle Fusco-Allison, Desmond K. Li, Benjamin Hunter, Dan Jackson, Paul G. Bannon, Sean Lal, John F. O’Sullivan. ESC Heart Failure 2021 Aug 2. doi: 10.1002/ehf2.13504. PMID: 34342166
Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health. Jibran A. Wali, Annabelle J. Milner, Alison W. S. Luk, Tamara J. Pulpitel, Tim Dodgson, Harrison J. W. Facey, Devin Wahl, Melkam A. Kebede, Alistair M. Senior, Mitchell A. Sullivan, Amanda E. Brandon, Belinda Yau, Glen P. Lockwood, Yen Chin Koay, Rosilene Ribeiro, Samantha M. Solon-Biet, Kim S. Bell-Anderson, John F. O’Sullivan, Laurence Macia, Josephine M. Forbes, Gregory J. Cooney, Victoria C. Cogger, Andrew Holmes, David Raubenheimer, David G. Le Couteur & Stephen J. Simpson Nature Metabolism, 3, 810–828 (2021)
Nutritional and metabolic regulation of the metabolite Dimethylguanidino Valeric Acid – an early marker of cardiometabolic disease. Jibran A. Wali*, Yen Chin Koay*, Jason Chami, Courtney Wood, Roman Rodionov, Andreas Birkenfeld, Dorit Samocha-Bonet, Stephen J. Simpson, John F. O’Sullivan. AJP – Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00207.2020. PMID: 32663097; PMCID: PMC7509244.
Cardio-Metabolic Effects of High-Fat Diets and Their Underlying Mechanisms. Jibran A. Wali, Natalia Jarzebska, David Rubenheimer, Stephen J. Simpson, Roman Rodionov, John F. O’Sullivan. Nutrients. 2020 May; 12(5): 1505. PMCID: PMC7284903. PMID: 32455838.
Disulfiram Treatment Normalizes Body Weight in Obese Mice. Michel Bernier, Sarah J. Mitchell, Devin Wahl, Antonio Diaz, Abhishek Singh, Wonhyo Seo, Mingy Wang, Ahmed Ali, Tamzin Kaiser, Nathan L. Price, Miguel A. Aon, Eun-Young Kim, Michael A. Petr, Huan Cai, Alessa Warren, Clara Di Germanio, Andrea Di Francesco, Ken Fishbein, Vince Guiterrez, Dylan Harney, Yen Chin Koay, John Mach, Ignacio Navas Enamorado, Tamara Pulpitel, Yushi Wang, Jing Zhang, Li Zhang, Richard G. Spencer, Kevin G. Becker, Josephine M. Egan, Edward G. Lakatta, John O’Sullivan, Mark Larance, David G. LeCouteur, Victoria C. Cogger, Bin Gao, Carlos Fernandez-Hernando, Ana Maria Cuervo, Rafael de Cabo. Cell Metabolism, 2020 https://doi.org/10.1016/j.cmet.2020.04.019. PMID: 32413333
Plasma Levels of TMAO can be Increased with ‘Healthy’ and ‘Unhealthy’ Diets and Do Not Correlate with the Extent of Atherosclerosis but with Plaque Instability. Yen Chin Koay#, Yung-Chih Chen#, Jibran A. Wali, Alison W. S. Luk, Mengbo Li, Hemavarni Doma, Rosa Reimark, Habteab T. Habtom, Ashley E. Frank, Gabrielle Fusco-Allison, Jean Yang, Andrew Holmes, Stephen J. Simpson, Karlheinz Peter, John F. O’Sullivan. Cardiovasc Res. 2021 Jan 21;117(2):435-449. pii: cvaa094. doi: 10.1093/cvr/cvaa094. PMID: 32267921
Effect of chronic exercise in healthy young male adults: a metabolomic analysis. Yen Chin Koay, Kelly Stanton, Vivian Kienzle, Mengbo Li, Jean Yang, David S. Celermajer, John F. O’Sullivan. Cardiovasc Res. 2021 Jan 21;117(2):613-622. pii: cvaa051. doi: 10.1093/cvr/cvaa051. PMID: 32239128
Systems Proteomics of the Intermittent Fasting Response Identifies an Unexpected Role for HNF4α Luke Hatchwell, Dylan J. Harney, Michelle Cielesh, Kieren Young, Yen Chin Koay, John F. O’Sullivan, Mark Larance. Cell Rep. 2020 Mar 10;30(10):3566-3582.e4. doi: 10.1016/j.celrep.2020.02.051. PMID: 32160557
Ingestion of resistant starch by mice markedly increases microbiome-derived metabolites. Yen Chin Koay*, Jibran A. Wali*, Alison W. S. Luk, Laurence Macia, Victoria C. Cogger, Tamara J. Pulpitel, Devin Wahl, Samantha M. Solon-Biet, Andrew Holmes, Stephen J. Simpson, John F. O’Sullivan. FASEB J 2019. Mar 29:fj201900177R. doi: 10.1096/fj.201900177R. PMID: 30925066.
Myocardial Metabolic Perturbations in Advanced Ischemic and Non-Ischemic Dilated Human Heart Failure. Jacob Cao, Yen Chin Koay, Lake-Ee Quek, Benjamin Parker, Sean Lal*, John F. O’Sullivan*. European Journal of Heart Failure, 2019 Aug;21(8):1042-1045. doi: 10.1002/ejhf.1479. Epub 2019 Jun 11. PMID: 31184404.
Ingestion of resistant starch by mice markedly increases microbiome-derived metabolites. Yen Chin Koay*, Jibran A. Wali*, Alison W. S. Luk, Laurence Macia, Victoria C. Cogger, Tamara J. Pulpitel, Devin Wahl, Samantha M. Solon-Biet, Andrew Holmes, Stephen J. Simpson, John F. O’Sullivan. FASEB J 2019. Mar 29:fj201900177R. doi: 10.1096/fj.201900177R. PMID: 30925066.
Metabolites downstream of predicted loss-of-function variants inform relationship to disease. Mengbo Li, Andy Wang, Lake-Ee Quek, Stephen Vernon, Gemma A. Figtree, Jean Yang, John F. O’Sullivan. Mol Genetics and Metab (https://doi.org/10.1016/j.ymgme.2019.10.002) (Epub ahead of print).
MiRNA93-5p is a Novel Predictor of Coronary Artery Instent Restenosis. John F. O’Sullivan, Antoinette Neylon, Eoin F. Fahey, Pengyi Yang, Catherine McGorrian, Gavin J. Blake. Heart Asia. 2019 Feb 22;11(1):e011134. doi: 10.1136/heartasia-2018-011134. eCollection 2019. PMID: 31031831.
Branched chain amino acids impact health and lifespan indirectly via diet balance and appetite control. Samantha M Solon-Biet, Victoria C Cogger, Tamara Pulpitel, Devin Wahl, Ximonie Clark, Alistair Senior, Qiaoping Wang, Amanda Brandon, Ruth Perks, John F. O’Sullivan, Yen C Koay, Kim Bell-Anderson, Melkam Kebede, Belinda Yau, Clare Atkinson, Gunbjorg Svineng, Rosilene Waern, Jibran A Wali, Matthew D Piper, Robert Cumming Vasant Hirani, David J Handelsman, Paula Juricic, Linda Partridge, David Raubenheimer, Gregory Cooney, David G Le Couteur , Stephen J Simpson. Nature Metabolism, volume 1, pages532–545 (2019).
Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes. John F O’Sullivan, Jordan E Morningstar, Baohui Zheng, Sarah Jeanfavre, Justin Scot, Qiong Yang, Celine Fernandez, Ramachandran S. Vasan, Michelle T. Long, Olle Melander, Thomas J. Wang, Caroline Fox, Randall T. Peterson, Clary Clish, Kathleen Corey, Robert E. Gerszten. J Clin Invest. 2017 Dec 1;127(12):4394-4402. PMID: 29083323.
Metabolite Profiles and the Risk of Cardiometabolic Disease. O’Sullivan J, Gerszten RE Eur Heart J 2014; 35; 2197–2204. DOI: 10.1093/eurheartj/ehu270.
Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Curtis R. Warren, John F. O’Sullivan, Max Friesen, Caroline E. Becker, Xiaoling Zhang, Yoshi Wakabayashi, Jordan E. Morningstar, Xu Shi, Jihoon Choi, Fang Xia, Mary H. C. Florido, Jennifer Shay, Derek T. Peters, Kiran Musunuru, Sekar Kathiresan, Laurence Daheron, Jun Zhu, Robert E. Gerszten, Rahul Deo, Vasan Ramachandran, Christopher J. O’Donnell, and Chad A. Cowan. Cell Stem Cell 2017 Apr 6;20(4):547-557. PMID: 28388431.
Metabolite Profiling Identifies Anandamide as a Biomarker of Nonalcoholic Steatohepatitis. Taylor Kimberly, John O’Sullivan, Anjali Nath, Michelle Keyes, Qiong Yang, Martin G. Larson, Vasan Ramachandran, Randall T. Peterson, Thomas J. Wang, Kathleen Corey, and Robert E. Gerszten. J Clin Invest. Insight 2017 May 4;2(9). PMID: 28469090.
Aptamer-based proteomic profiling reveals novel candidate biomarkers of cardiovascular disease. Debby Ngo, Sumita Sinha, Dongxiao Shen, Eric Kuhn, Michelle Keyes, Xu Shi, Mark Benson, John F. O’Sullivan, Hasmik Keshishian, Laurie Farrell, Michael A. Fifer, Ramachandran S. Vasan, Marc Sabatine, Martin G. Larson , Steven A. Carr, Thomas J. Wang, Robert E. Gerszten. Circulation 2016; 134:270-285. PMID: 27444932.
Integrative analysis of iPS cell models of PRKAG2 cardiomyopathy identifies AMPK as a regulator of cardiomyocyte survival, contractility and fibrosis in microtissues. Travis Hinson, Anant Chopra, Calvin C. Sheng, Rajat M. Gupta, Rajarajan Kuppusamy, John F. O’Sullivan, Glenn Rowe, Joshua Gorham, Kiran Musunuru, Robert E. Gerszten, Sean M. Wu, Christopher Chen, Jonathan E. Seidman, Christine E. Seidman. Cell Reports 2016 Dec 20;17(12):3292-3304. PMID: 28009297.
Rapid and efficient generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Christoph Patsch, Ludivine Challet-Meylan, Eva Christina Thoma, Eduard Urich, Tobias Heckel, John F O’Sullivan, Stephanie J Grainger, Friedrich G Karpp, Lin Sun, Klaus Christensen, Yulei Xia, Marie Florido, Wei He, Wei Pan, Michael Prummer, Curtis Warren, Oliver Wernet, Roland Jakob-Roetne, Ulrich Certa, Ravi Jagasia, Per-Ola Freskgård, Isaac Adatto, Dorothee Kling, Paul Huang, Leonard I Zon, Elliot Chaikof, Robert E. Gerzsten, Martin Graf, Roberto Iacone and Chad A. Cowan. Nature Cell Biology 2015 Aug;17(8):994-1003. PMID: 26214132.
Increases in Myocardial Workload Induced by Rapid Atrial Pacing Trigger Alterations in Global Metabolism. Turer AT, Lewis GD, O’Sullivan JF, Elmariah S, Mega JL, Addo TA, Sabatine MS, de Lemos JA, Gerszten RE. PLoS One. 2014 Jun 16;9(6):e99058. PMID: 24932507.
β-Aminoisobutyric Acid Increases Browning of White Fat and Hepatic β-Oxidation and is Inversely Correlated with Cardiometabolic Risk Factors in Humans. Lee D. Roberts, Pontus Boström, John F. O’Sullivan, Robert T. Schinzel, Gregory D. Lewis, Youn-Kyoung Lee, Melinda J. Palma, Sondra Calhoun, Ming-Huei Chen, Vasan S. Ramachandran, Martin G. Larson, Claude Bouchard, Tuomo Rankinen, Amanda L. Souza, Clary B. Clish, Thomas J. Wang, Alexander A. Soukas, Chad A. Cowan, Bruce M. Spiegelman, Robert E. Gerszten. Cell Metabolism Volume 19, Issue 1, 96-108, 7 January 2014. PMID: 24411942.
2-aminoadipic acid is a novel biomarker of diabetes risk and modulates glucose homeostasis. Wang TJ, Ngo D, Psychogios N, Dejam A, Larson MG, Vasan RS, Ghorbani A, O’Sullivan J, Cheng S, Rhee EP, Sinha S, McCabe E, Fox CS, O’Donnell CJ, Ho JE, Florez JC, Magnusson M, Pierce KA, Souza AL, Yu Y, Carter C, Light PE, Melander O, Clish CB, Gerszten RE. J Clin Invest. 2013 Oct 1;123(10):4309-4317. PMID: 24091325.
Multi Detector Computed Tomography Accurately Defines Infarct Size, but not Microvascular Obstruction After Myocardial Infarction (MI). John F O’Sullivan, MD, PhD, Anne-Laure Leblond, PhD, John O’Dea, MD, Ivalina Hristova, BS, Sujith Kumar, DMRIT, Noel M Caplice, MD, PhD. J Am Coll Cardiol. 2013;61(2):208-210. PMID: 23177294.
Microribonucleic acids for Prevention of Plaque Rupture and Instent Restenosis: “A Finger in the Dam”. John F O’Sullivan, Kenneth Martin, Noel M Caplice. State of the Art Paper. J Am Coll Cardiol 2011 Jan 25;57(4):383-9. PMID: 21251577.
Potent Long-term Cardioprotective Effects of Single Low Dose Insulin-like Growth Factor-1 (LD-IGF-1) Treatment Post Myocardial Infarction. John F O’Sullivan, Anne-Laure Leblond, Geraldine Kelly, Arun HS Kumar, Pat Metharom, Ivalina Hristova, Niki Alizadeh-Vikali, Brian G Hynes, Rosemary O’Connor, Noel M Caplice. Circulation: Cardiovascular Interventions 2011;4:327-335. PMID: 21712526.
Potent EPC conditioned media induced anti-apoptotic, cardiotrophic and proangiogenic effects post myocardial infarction are mediated by IGF1. Brian Hynes, Arun HS Kumar, John O’Sullivan, Anne-Laure Leblond, Sharon Weiss, Jeffrey Schmeckpeper, Kenneth Martin, Noel M Caplice. Eur Heart J 2011 Dec 15. PMID: 22173909.
Thrombin Stimulates Smooth Muscle Cell Differentiation From Peripheral Blood Mononuclear Cells via Protease-Activated Receptor-1, RhoA, and Myocardin. Kenneth Martin, Sharon Weiss, Pat Metharom, Jeffrey S Schmeckpeper, Brian G Hynes, John F O’Sullivan, Noel M Caplice. Circulation Research 2009;105:214-218. PMID: 19574550.
Soft tissue neoplasm invading the heart with associated thrombus in a 74 year old man. John O’Sullivan, David Kerins, Peter McEneaney, Carl Vaughan Eur J Echocardiogr. 2007 Jul 30. PMID: 17669689.
Massive thrombus in the aortic arch: A 59-year-old lady with an unknown familial predisposition to vascular thrombosis. O’Sullivan J, Kerins D, Vaughan C. Eur J Echocardiogr. 2007 Sep 19. PMID: 17888744.